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In the early 1990s, scientists made the groundbreaking discovery of nitric oxide and named it “molecule of the year” for its many functions in the human body. The researchers who made the discovery were awarded the Nobel Prize for their pivotal scientific research. One of the most crucial roles of nitric oxide is its positive influence on the cardiovascular system. Here’s what you need to know.   

What is Nitric Oxide?

Nitric oxide (NO) is a soluble gas continuously produced by the endothelium throughout the body. It’s made by the endothelial cells lining the blood vessels and causes relaxation in the vascular smooth muscle cells. That relaxation causes vasodilation (blood vessel expansion), increasing blood flow. The improved blood flow due to dilation increases oxygen delivery by the red blood cells. 

Nitric oxide is a signaling molecule at its core and serves a vital role as a neurotransmitter in the central nervous system (CNS). Because of the part it plays in communication, it’s produced in most cells of the body. Nitric oxide also helps the immune system fight off invading pathogens like bacteria and viruses.  

When exposed to a pathogen, our body’s normal reaction is to mobilize an immune response, which immediately goes to the site of infection. When that happens, our immune cells produce nitric oxide to suppress bacterial respiration and prevent viruses from replicating. 

Nitric oxide also has several properties that help it protect the cardiovascular system, including: [1] 

  • Inhibition of platelet aggregation and adhesion to endothelial cells (reducing the risk of atherosclerosis) 
  • Protecting against endothelial dysfunction 
  • Regulation of blood pressure and vascular tone 
  • Prevention of smooth muscle cell proliferation  

That’s why nitric oxide deficiency is a significant risk factor in developing vascular diseases like heart disease and stroke.  

What Happens if Your Nitric Oxide Goes Down?

Many things can go wrong when you lose the ability to produce nitric oxide. You can develop one or more of the following symptoms:  

  • High blood pressure 
  • Blood clots 
  • High cholesterol   
  • Myocardial infarction (heart attack) 
  • Sexual dysfunction 
  • Hypoxemia (low blood oxygen) 
  • Compromised immune system 
  • Inability to heal 
  • Advanced aging 

The loss of nitric oxide is the earliest event in the progression of almost every chronic human disease. 

Low Nitric Oxide Can Lead to High Blood Pressure

The #1 modifiable risk factor for cardiovascular disease is hypertension (high blood pressure). If you go to your doctor with elevated blood pressure, they’ll typically put you on an ACE inhibitor, an ARB (Angiotensin II Receptor Blocker), a Calcium channel antagonist, or a diuretic.  

If you have an old-school doctor, they’ll put you on a beta-blocker, one of the worst drugs on the market. [2]  

According to Dr. Nathan Bryan, the scientific data shows that 50 percent of those given a blood pressure-lowering medication don’t experience balanced blood pressure. Dr. Bryan discovered and published research showing that high blood pressure is a symptom of oral dysbiosis. That’s why blood pressure isn’t always affected by blood pressure meds. [3]  

People with high blood pressure almost always have insufficient nitric oxide production. Except for those with heavy metal toxicities, their blood pressure always normalizes if you restore nitric oxide production.  

It’s critical to get to the root causes of the disease and fix the underlying problems. That’s where Western medicine has failed us for hundreds of years. They never understand the contributing causes of the disease. Instead, they prescribe drugs to mask the problem and never address the underlying issues. 

The human body is designed to heal itself. We just need to give it what it needs. 

Nitric Oxide Deficiency: Symptoms and Testing

If you have these diagnoses, signs, or symptoms, you’re likely nitric oxide deficient: 

  • Metabolic syndrome 
  • Elevation in blood pressure 
  • Sexual dysfunction 
  • Elevation in triglycerides 
  • Elevation in C-reactive protein and other inflammatory markers

There aren’t blood tests for nitric oxide because it’s a gas and dissipates in less than a second. Instead, Dr. Bryan developed a salivary test trip to help you figure out whether your body can produce nitric oxide.  

Here’s how it works: You apply your saliva to the test strip, and if it turns pink, it tells us that your body can produce and regenerate nitric oxide. If it doesn’t turn pink, you’re deficient. While there are occasional false positives, there are no false negatives.  

Signs and symptoms are reliable indicators of nitric oxide deficiency. 

How Do You Increase Your Nitric Oxide?

Nitric oxide is essential for healing, and your body cannot fully heal without restoring nitric oxide levels. To restore production, you need to do two things: 

  1. Stop doing the things that disrupt nitric oxide production. 
  2. Start doing the things proven clinically to restore and stimulate your nitric oxide production. 

Stop Doing These Things That Disrupt Nitric Oxide Production:

  • Using mouthwash – Mouthwash disrupts your oral microbiome and causes blood pressure to go up. [4] 
  • Fluoride exposure – Get rid of fluoride in your toothpaste. It kills bacteria in the mouth, it’s a neurotoxin, and it damages your thyroid. It’s also been shown to inhibit the synthesis of nitric oxide. [5] 
  • Taking antacids – Antacids lower your stomach acid, inhibiting nitric oxide production and increasing your risk of developing a whole host of immune system problems, foodborne illness, parasites, autoimmunity, and more. [6] 

If you cut these three things, your body will automatically improve its ability to produce nitric oxide. But there are other things you can add to increase your nitric oxide. 

Start Doing These Things That Increase Your Nitric Oxide:

  • Physical exercise – Get moderate physical activity, like aerobic exercise or strength training. [7] 
  • Green leafy vegetables – Eat more to increase your nitrate intake. Bacteria in the mouth reduce nitrates to nitrites, which are then reduced to nitric oxide in areas of low oxygen. [8]  
  • Beet root – Eating beets or drinking beet juice is known to increase concentrations of nitric oxide in the body. [9] 
  • Arginine-rich foods – Lentils, chickpeas, pumpkin seeds, sunflower seeds, and seaweed can increase the nitric oxide precursor, arginine. Dietary arginine is associated with a higher level of nitric oxide in the blood. [10] 
  • Antioxidant-rich foods – Food rich in vitamin C and other antioxidants can fight oxidative stress from free radicals and prolong the life of nitric oxide in the bloodstream. Vitamin C has also been shown to increase endothelial nitric oxide (eNO), improving endothelial function and reducing the risk of cardiovascular disease. [11] 
  • Breathing through the nose – Breathing through the nose and not the mouth increases the release of nitric oxide via the sinuses. [12] 
  • Humming – Humming increases nasal nitric oxide release by enhancing sinus ventilation. [13] 
  • Sunlight – Get some sunlight. Sun exposure releases nitric oxide in the skin via enzymes, including endothelial nitric oxide synthase (endothelial NOS or eNOS). [14] 
  • Lower your stress – Stress is the enemy of nitric oxide and nitric oxide synthase, an enzyme that converts L-arginine to nitric oxide. Stress lowers stomach acid, which is necessary for converting dietary nitrates into nitric oxide.

Following this strategy saves money. You don’t always have to spend money to preserve or restore your health. Instead, stop spending money on things that are shutting down nitric oxide production and then get out and exercise, get sunlight, de-stress, and walk barefoot on the ground. 

Supplement to Increase Nitric Oxide

“Diet and lifestyle” are always the first strategy for achieving or restoring health, but if all else fails, a supplement can help you increase nitric oxide naturally. This technology is the only one proven to generate nitric oxide gas in the body. The supplement is called Neo40®. 

Neo40 is a clinical-strength nitric oxide support. This patented formula helps the body naturally increase the production of nitric oxide (NO). This product is clinically researched to help promote artery dilation and increased circulation throughout the body. Healthy circulation is associated with many health benefits. [15] 

Put the tablet in your mouth, and your saliva activates the ingredients to generate nitric oxide. Plenty of peer-reviewed research backs up the effectiveness of this supplement. 

Nitric Oxide Has Great Potential for Other Chronic Diseases

We can now apply everything scientists have learned about nitric oxide to many poorly managed human diseases. It will likely change the landscape of healthcare and how we care for patients (Alzheimer’s, cardiovascular, diabetic, etc.) for the next hundred years. So far, advancements in medicine for these conditions have been very poor. All these major chronic metabolic diseases are at an all-time high. Nitric oxide may prove to be a better form of treatment for all of these. 

Give the body what it needs. When you do that, you restore physiology and everything works better: cells regenerate, tissues regenerate, and cells perform their functions as they are designed to do.  

Test Your Nitric Oxide and Cardiovascular Risk Factors

A nitric oxide deficiency is only one risk factor for heart disease. As the Swiss Watch Principle states, even if the smallest gear stops working, it affects everything else, and the clock will no longer keep proper time. You cannot treat the body like a bunch of disconnected gears. Thyroid hormones, inflammation levels, and infections can increase your cardiovascular risk. Don’t hesitate; reach out to a Wellness Way clinic today.  

In the early 1990s, scientists made the groundbreaking discovery of nitric oxide and named it “molecule of the year” for its many functions in the human body. The researchers who made the discovery were awarded the Nobel Prize for their pivotal scientific research. One of the most crucial roles of nitric oxide is its positive influence on the cardiovascular system. Here’s what you need to know.   

What is Nitric Oxide?

Nitric oxide (NO) is a soluble gas continuously produced by the endothelium throughout the body. It’s made by the endothelial cells lining the blood vessels and causes relaxation in the vascular smooth muscle cells. That relaxation causes vasodilation (blood vessel expansion), increasing blood flow. The improved blood flow due to dilation increases oxygen delivery by the red blood cells. 

Nitric oxide is a signaling molecule at its core and serves a vital role as a neurotransmitter in the central nervous system (CNS). Because of the part it plays in communication, it’s produced in most cells of the body. Nitric oxide also helps the immune system fight off invading pathogens like bacteria and viruses.  

When exposed to a pathogen, our body’s normal reaction is to mobilize an immune response, which immediately goes to the site of infection. When that happens, our immune cells produce nitric oxide to suppress bacterial respiration and prevent viruses from replicating. 

Nitric oxide also has several properties that help it protect the cardiovascular system, including: [1] 

  • Inhibition of platelet aggregation and adhesion to endothelial cells (reducing the risk of atherosclerosis) 
  • Protecting against endothelial dysfunction 
  • Regulation of blood pressure and vascular tone 
  • Prevention of smooth muscle cell proliferation  

That’s why nitric oxide deficiency is a significant risk factor in developing vascular diseases like heart disease and stroke.  

What Happens if Your Nitric Oxide Goes Down?

Many things can go wrong when you lose the ability to produce nitric oxide. You can develop one or more of the following symptoms:  

  • High blood pressure 
  • Blood clots 
  • High cholesterol   
  • Myocardial infarction (heart attack) 
  • Sexual dysfunction 
  • Hypoxemia (low blood oxygen) 
  • Compromised immune system 
  • Inability to heal 
  • Advanced aging 

The loss of nitric oxide is the earliest event in the progression of almost every chronic human disease. 

Low Nitric Oxide Can Lead to High Blood Pressure

The #1 modifiable risk factor for cardiovascular disease is hypertension (high blood pressure). If you go to your doctor with elevated blood pressure, they’ll typically put you on an ACE inhibitor, an ARB (Angiotensin II Receptor Blocker), a Calcium channel antagonist, or a diuretic.  

If you have an old-school doctor, they’ll put you on a beta-blocker, one of the worst drugs on the market. [2]  

According to Dr. Nathan Bryan, the scientific data shows that 50 percent of those given a blood pressure-lowering medication don’t experience balanced blood pressure. Dr. Bryan discovered and published research showing that high blood pressure is a symptom of oral dysbiosis. That’s why blood pressure isn’t always affected by blood pressure meds. [3]  

People with high blood pressure almost always have insufficient nitric oxide production. Except for those with heavy metal toxicities, their blood pressure always normalizes if you restore nitric oxide production.  

It’s critical to get to the root causes of the disease and fix the underlying problems. That’s where Western medicine has failed us for hundreds of years. They never understand the contributing causes of the disease. Instead, they prescribe drugs to mask the problem and never address the underlying issues. 

The human body is designed to heal itself. We just need to give it what it needs. 

Nitric Oxide Deficiency: Symptoms and Testing

If you have these diagnoses, signs, or symptoms, you’re likely nitric oxide deficient: 

  • Metabolic syndrome 
  • Elevation in blood pressure 
  • Sexual dysfunction 
  • Elevation in triglycerides 
  • Elevation in C-reactive protein and other inflammatory markers

There aren’t blood tests for nitric oxide because it’s a gas and dissipates in less than a second. Instead, Dr. Bryan developed a salivary test trip to help you figure out whether your body can produce nitric oxide.  

Here’s how it works: You apply your saliva to the test strip, and if it turns pink, it tells us that your body can produce and regenerate nitric oxide. If it doesn’t turn pink, you’re deficient. While there are occasional false positives, there are no false negatives.  

Signs and symptoms are reliable indicators of nitric oxide deficiency. 

How Do You Increase Your Nitric Oxide?

Nitric oxide is essential for healing, and your body cannot fully heal without restoring nitric oxide levels. To restore production, you need to do two things: 

  1. Stop doing the things that disrupt nitric oxide production. 
  2. Start doing the things proven clinically to restore and stimulate your nitric oxide production. 

Stop Doing These Things That Disrupt Nitric Oxide Production:

  • Using mouthwash – Mouthwash disrupts your oral microbiome and causes blood pressure to go up. [4] 
  • Fluoride exposure – Get rid of fluoride in your toothpaste. It kills bacteria in the mouth, it’s a neurotoxin, and it damages your thyroid. It’s also been shown to inhibit the synthesis of nitric oxide. [5] 
  • Taking antacids – Antacids lower your stomach acid, inhibiting nitric oxide production and increasing your risk of developing a whole host of immune system problems, foodborne illness, parasites, autoimmunity, and more. [6] 

If you cut these three things, your body will automatically improve its ability to produce nitric oxide. But there are other things you can add to increase your nitric oxide. 

Start Doing These Things That Increase Your Nitric Oxide:

  • Physical exercise – Get moderate physical activity, like aerobic exercise or strength training. [7] 
  • Green leafy vegetables – Eat more to increase your nitrate intake. Bacteria in the mouth reduce nitrates to nitrites, which are then reduced to nitric oxide in areas of low oxygen. [8]  
  • Beet root – Eating beets or drinking beet juice is known to increase concentrations of nitric oxide in the body. [9] 
  • Arginine-rich foods – Lentils, chickpeas, pumpkin seeds, sunflower seeds, and seaweed can increase the nitric oxide precursor, arginine. Dietary arginine is associated with a higher level of nitric oxide in the blood. [10] 
  • Antioxidant-rich foods – Food rich in vitamin C and other antioxidants can fight oxidative stress from free radicals and prolong the life of nitric oxide in the bloodstream. Vitamin C has also been shown to increase endothelial nitric oxide (eNO), improving endothelial function and reducing the risk of cardiovascular disease. [11] 
  • Breathing through the nose – Breathing through the nose and not the mouth increases the release of nitric oxide via the sinuses. [12] 
  • Humming – Humming increases nasal nitric oxide release by enhancing sinus ventilation. [13] 
  • Sunlight – Get some sunlight. Sun exposure releases nitric oxide in the skin via enzymes, including endothelial nitric oxide synthase (endothelial NOS or eNOS). [14] 
  • Lower your stress – Stress is the enemy of nitric oxide and nitric oxide synthase, an enzyme that converts L-arginine to nitric oxide. Stress lowers stomach acid, which is necessary for converting dietary nitrates into nitric oxide.

Following this strategy saves money. You don’t always have to spend money to preserve or restore your health. Instead, stop spending money on things that are shutting down nitric oxide production and then get out and exercise, get sunlight, de-stress, and walk barefoot on the ground. 

Supplement to Increase Nitric Oxide

“Diet and lifestyle” are always the first strategy for achieving or restoring health, but if all else fails, a supplement can help you increase nitric oxide naturally. This technology is the only one proven to generate nitric oxide gas in the body. The supplement is called Neo40®. 

Neo40 is a clinical-strength nitric oxide support. This patented formula helps the body naturally increase the production of nitric oxide (NO). This product is clinically researched to help promote artery dilation and increased circulation throughout the body. Healthy circulation is associated with many health benefits. [15] 

Put the tablet in your mouth, and your saliva activates the ingredients to generate nitric oxide. Plenty of peer-reviewed research backs up the effectiveness of this supplement. 

Nitric Oxide Has Great Potential for Other Chronic Diseases

We can now apply everything scientists have learned about nitric oxide to many poorly managed human diseases. It will likely change the landscape of healthcare and how we care for patients (Alzheimer’s, cardiovascular, diabetic, etc.) for the next hundred years. 

So far, advancements in medicine for these conditions have been very poor. All these major chronic metabolic diseases are at an all-time high. Nitric oxide may prove to be a better form of treatment for all of these. 

Give the body what it needs. When you do that, you restore physiology and everything works better: cells regenerate, tissues regenerate, and cells perform their functions as they are designed to do.  

Test Your Nitric Oxide and Cardiovascular Risk Factors

A nitric oxide deficiency is only one risk factor for heart disease. As the Swiss Watch Principle states, even if the smallest gear stops working, it affects everything else, and the clock will no longer keep proper time. You cannot treat the body like a bunch of disconnected gears. Thyroid hormones, inflammation levels, and infections can increase your cardiovascular risk. Don’t hesitate; reach out to a Wellness Way clinic today.  

References:

  1. The role of nitric oxide in cardiovascular diseases – PubMed (nih.gov)
  2. Beta-Blockers Are Not So Great (medicalnewstoday.com)
  3. Good Mouth Bacteria are Necessary for Optimal Nitric Oxide Production: Are Common Dental Hygienic Practices Putting us at Risk for Heart Disease? – Dr. Nathan Bryan – Molecular medicine and nitric oxide biochemistry (drnathansbryan.com)
  4. Over-the-counter mouthwash use, nitric oxide and hypertension risk – PubMed (nih.gov)
  5. Preliminary Study of Mechanisms of Fluoride-Induced Suppression of Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells – PubMed (nih.gov)
  6. UNDERSTAND THE RISK OF TAKING ANTACID DRUGS, HOW THEY LEAD TO INCREASED DEATH AND WHAT YOU CAN DO TO AVOID DEATH FROM THESE DRUGS – Dr. Nathan Bryan – Molecular medicine and nitric oxide biochemistry (drnathansbryan.com)
  7. Effect of exercise training on endothelium-derived nitric oxide function in humans – PubMed (nih.gov)
  8. Dietary Nitrate and Nitric Oxide Metabolism: Mouth, Circulation, Skeletal Muscle, and Exercise Performance – PubMed (nih.gov)
  9. Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review – PubMed (nih.gov)
  10. The Association of Dietary l-Arginine Intake and Serum Nitric Oxide Metabolites in Adults: A Population-Based Study – PMC (nih.gov)
  11. Vitamin C for Type 2 Diabetes Mellitus and Hypertension – PubMed (nih.gov)
  12. Comparison of exhaled nitric oxide and cardiorespiratory indices between nasal and oral breathing during submaximal exercise in humans – PubMed (nih.gov)
  13. Humming greatly increases nasal nitric oxide – PubMed (nih.gov)
  14. Insufficient Sun Exposure Has Become a Real Public Health Problem – PubMed (nih.gov)
  15. All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans – PubMed (nih.gov)

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Disclaimer: This content is for educational purposes only. It’s not intended as a substitute for the advice provided by your Wellness Way clinic or personal physician, especially if currently taking prescription or over-the-counter medications. Pregnant women, in particular, should seek the advice of a physician before trying any herb or supplement listed on this website. Always speak with your individual clinic before adding any medication, herb, or nutritional supplement to your health protocol. Information and statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease.

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