Ross C. Larue and Amit Sharma are both researchers based at the University of Ohio. Along with their colleagues, they discovered a way in which peptides ‘trick’ the SARS-CoV-2 Virus that it latched onto a host cell, thereby deactivating it. Their findings were published in the Bioconjugate Chemistry journal.
The researchers state that “Spike proteins are essential for viral replication as they mediate viral entry into the host cell.” (1)
The Spike glycoproteins bind the host angiotensin-converting enzyme 2 (ACE2) receptor through their receptor binding domains (RBDs), specifically.
Through an extensive research and study process, the researchers found two specific peptides which resembled the spiral-like tail on an ACE2 receptor. The Spike glycoproteins on the SARS-CoV-2 virus attach to these peptides.
Promising results came from the study as the viral particles were deactivated once they latched to the peptides, reducing the possibility of viral replication.
The researchers are in the process of patenting their findings, meaning their product could be hitting the shelves soon.