Research Cardiovascular

Cardiovascular Studies

Acute fulminant myocarditis after diphtheria, polio, and tetanus vaccination.

“We report an infant case of acute fulminant myocarditis which occurred after administration of a diphtheria, polio, and tetanus vaccination. Fever and dyspnea developed after the vaccination. Extracorporeal membrane oxygenation was used for intractable cardiogenic shock. The patient survived the extracorporeal support, but poor ventricular contractility recurred 2 months later and she died while waiting for heart transplantation.”
#DTP #Myocarditis #Cardiovascular #Vaccine #MedScienceResearch

Acute myopericarditis after multiple vaccinations in an adolescent: case report and review of the literature.

“We report a case of postvaccination acute myopericarditis in an adolescent. The patient presented with acute chest pain, diffuse ST-segment elevation, and elevated cardiac enzyme levels. Cardiac MRI was consistent with acute myocarditis. He recovered within a few days with nonsteroidal antiinflammatory treatment and remains clinically stable, with improvement of MRI findings at the 10-week follow-up. Postvaccination cases of myopericarditis reported in the pediatric literature are also reviewed.”
#Cardiovascular #Vaccine

Adverse events following vaccination in premature infants.

“Apparent adverse events were noted in 17 of 45 (37.8%) babies: 9 (20%) had major events, i.e. apnoea, bradycardia or desaturations, and 8 (17.8%) had minor events, i.e. increased oxygen requirements, temperature instability, poor handling and feed intolerance. Babies with major events were significantly younger (p < 0.05), had a lower postmenstrual age (p < 0.05) and weighed less (p < 0.05) at the time of vaccination compared with babies without major events."
"CONCLUSION: Vaccine-related cardiorespiratory events are relatively common in preterm babies. Problems were much more common if vaccine is administered at or before 70 d. These babies should therefore be monitored postvaccination."
#Premature #Cardiorespiratory #Near #Miss #DTP #Hib #Bradycardia #Apnea #Respiratory #Cardiovascular

Apnea after immunization of preterm infants.

“However, 12 (12%) infants experienced a recurrence of apnea, and 11 (11%) had at least a 50% increase in the number of apneic and bradycardic episodes in the 72 hours after immunization.”
#Premature #Cardiorespiratory #Near #Miss #DTP #Hib #Bradycardia #Apnea #Respiratory #Cardiovascular

A case of sudden death after Japanese encephalitis vaccination.

#Death #Japanese #Encephalitis #Cardiovascular #Vaccine #MedScienceResearch

Case report: Chest pain in service members following smallpox vaccination.

No abstract available
PMID 22452714
#Cardiovascular #Smallpox #Vaccine #MedScienceResearch

Chest pain, ST elevation, and positive cardiac enzymes in an austere environment: differentiating smallpox vaccination-mediated myocarditis and acute coronary syndrome in Operation Iraqi Freedom.

#Cardiovascular #Smallpox #Myocarditis #Vaccine #MedScienceResearch

Identifying birth defects in automated data sources in the Vaccine Safety Datalink. 2017

“Cardiac defects were most common (65.4 per 10 000 live births), with one-fourth classified as severe, requiring emergent intervention.”
#Pregnancy #Cardiovascular

Incidence of apnoea and bradycardia in preterm infants following triple antigen immunization.

“Ninety-seven preterm infants were immunized with diphtheria-tetanus-pertussis (DTP) prior to discharge from hospital. The mean gestational age at birth was 28.1 weeks (range 24-34) and the mean age at immunization was 80.6 days (range 44-257). Nineteen (20%) infants developed apnoea or bradycardia within 24 h of immunization. The infants who developed apnoea and/or bradycardia had a younger gestational age at birth than those who did not (P = 0.03), were artificially ventilated for longer (P = 0.01) and were more likely to have a diagnosis of chronic lung disease (P = 0.006). In the majority of infants these events were not clinically significant. Two infants who developed concurrent upper respiratory tract infections required additional oxygen and one of them was treated with oral theophylline. In general, it is safe practice to immunize preterm infants with DTP unless otherwise contraindicated. However, it is recommended that cardiorespiratory function is monitored after immunization in very preterm infants who had prolonged ventilatory support and/or chronic lung disease.”
#Cardiorespiratory #Premature #Apnea #Near #Miss #DTP

Inflammation-related effects of adjuvant influenza A vaccination on platelet activation and cardiac autonomic function.

#Adjuvant #Cardiovascular #Heart #Influenza #Flu

Possible predictors of cardiorespiratory events after immunization in preterm neonates.

“Immunization was performed on 31 very preterm infants [28 weeks’ gestation (26.9-29), birth weight: 965 g (795-1,105)], and was associated with an increased incidence (p < 0.01) of events lasting more than 10 s: bradycardia <80 bpm [2.2 (1.1-7) vs. 1.8 (1-4)/12 h], desaturation [17.6 (9.4-36.4) vs. 13.9 (7.7-33.8)/12 h] and associated bradycardia-desaturation [IB+D, 4.1 (1.4-7.3) vs. 2.4 (1-4.6)/12 h], with mild changes in HRV and no change in RRV."
"The increase in CR events after the first immunization in very preterm infants was associated with: (1) sympathetic predominance in heart rate control (high LF/HF ratio), (2) abnormal oversimplification of HRV (low entropy) and (3) persistent respiratory rhythm control immaturity (high IB+D before vaccine)."

Potential cross-reactivity between HPV16 L1 protein and sudden death-associated antigens.

“In exploring the primary sequence of the human papilloma virus (HPV) 16 major capsid L1 protein for peptide sharing with human proteins, we find that 34 pentamers from the viral capsid protein are shared with human proteins that, when altered, have been linked to short QT syndrome, arrhythmogenic cardiac disorders, cardiovascular diseases and sudden death. In particular, nine out of the 34 viral pentamers are present in a human protein, titin, alterations of which have been linked to cardiac failure and sudden cardiac death. The present data may help evaluate the potential crossreactivity risks in anti-tumor vaccination protocols based on HPV16 L1 protein.”
#Gardasil #Death #Cardiovascular

Recurrence of cardiorespiratory events following repeat DTaP-based combined immunization in very low birth weight premature infants.

#DTaP #Respiratory #Cardiovascular #Vaccine #Premature #Cardiorespiratory #MedScienceResearch

A report of 2 cases of myopericarditis after Vaccinia virus (smallpox) immunization.

#Smallpox #Cardiovascular #Vaccine #MedScienceResearch