DTP Studies

Acute Autoimmune Hemolytic Anemia Following DTP Vaccination: Report of a Fatal Case and Review of the Literature

#Anemia #Death #Autoimmunity #DTP #AIHA #Vaccine


Acute fulminant myocarditis after diphtheria, polio, and tetanus vaccination.

“We report an infant case of acute fulminant myocarditis which occurred after administration of a diphtheria, polio, and tetanus vaccination. Fever and dyspnea developed after the vaccination. Extracorporeal membrane oxygenation was used for intractable cardiogenic shock. The patient survived the extracorporeal support, but poor ventricular contractility recurred 2 months later and she died while waiting for heart transplantation.”
#DTP #Myocarditis #Cardiovascular #Vaccine #MedScienceResearch


Adverse events following vaccination in premature infants.

“Apparent adverse events were noted in 17 of 45 (37.8%) babies: 9 (20%) had major events, i.e. apnoea, bradycardia or desaturations, and 8 (17.8%) had minor events, i.e. increased oxygen requirements, temperature instability, poor handling and feed intolerance. Babies with major events were significantly younger (p < 0.05), had a lower postmenstrual age (p < 0.05) and weighed less (p < 0.05) at the time of vaccination compared with babies without major events."
"CONCLUSION: Vaccine-related cardiorespiratory events are relatively common in preterm babies. Problems were much more common if vaccine is administered at or before 70 d. These babies should therefore be monitored postvaccination."
#Premature #Cardiorespiratory #Near #Miss #DTP #Hib #Bradycardia #Apnea #Respiratory #Cardiovascular


Adverse reactions after injection of adsorbed diphtheria-pertussis-tetanus (DPT) vaccine are not due only to pertussis organisms or pertussis components in the vaccine.

#DTP #Aluminum #Vaccine #MedScienceResearch


Apnea after immunization of preterm infants.

“However, 12 (12%) infants experienced a recurrence of apnea, and 11 (11%) had at least a 50% increase in the number of apneic and bradycardic episodes in the 72 hours after immunization.”
#Premature #Cardiorespiratory #Near #Miss #DTP #Hib #Bradycardia #Apnea #Respiratory #Cardiovascular


Back to the basics: hemorrhage after vaccination: a case report.

#DTP #Vaccine #MedScienceResearch


A case of Kawasaki disease with reaction at a DPT vaccination scar site.

Paranavithana S, et al. Ceylon Med J. 2003.
No abstract available
PMID 12971215
#Kawasaki #DTP #Vaccine #MedScienceResearch


Clinical implications of endotoxin concentrations in vaccines.

#Contamination #Vaccine #DTP #MedScienceResearch


DTaP with or after measles vaccination increased in-hospital mortality in Guinea-Bissau.

“RESULT: The case fatality was increased for children who had received DTP with or after measles vaccine compared with children who had received measles vaccine as the most recent vaccine, the ratio being 2.53 (1.37-4.67) and 1.77 (0.92-3.41) in the two periods, respectively.”
#Death #DTaP #DTP #Measles #MMR #Vaccine #MedScienceResearch


Effects of diphtheria-tetanus-pertussis or tetanus vaccination on allergies and allergy-related respiratory symptoms among children and adolescents in the United States.

“The odds of having a history of asthma was twice as great among vaccinated subjects than among unvaccinated subjects”
“DTP or tetanus vaccination appears to increase the risk of allergies and related respiratory symptoms in children and adolescents.”
#DTP #Allergies #Asthma #Autoimmunity #Vaccines #MedScienceResearch


An evaluation of the effects of thimerosal on neurodevelopmental disorders reported following DTP and Hib vaccines in comparison to DTPH vaccine in the United States.

“Significantly increased odds ratios for autism, speech disorders, mental retardation, infantile spasms, and thinking abnormalities reported to VAERS were found following DTP vaccines in comparison to DTPH vaccines with minimal bias or systematic error.”
#Autism #Psychiatric #DTP #Hib #Thimerosal #Mercury #Neurodevelopmental #VAERS #Vaccine #MedScienceResearch


Hypotonic and hyporesponsive episodes after diptheria-tetanus-acellular pertussis vaccination.

“Administration of the discontinued diphtheria-pertussis-tetanus vaccine was occasionally associated with a hypotonic-hyporesponsive episode in infants. The whole bacterial cell pertussis component was the likely culprit. For this reason, an acellular pertussis component was developed and incorporated into a new vaccine commonly called diptheria-tetanus-acellular pertussis (DTaP). Administration of DTaP vaccine has been followed by remarkably few hypotonic or hyporesponsive episodes. This report describes one of these unusual events.”
#Hypotonic #Hyporesponsive #DTAP #HHE #DTP #Vaccine


Hypotonic-hyporesponsive episodes after administration of hexavalent DTP-based combination vaccine: A description of 12 cases. (2017)

“Hypotonic-hyporesponsive (HHE) episodes are known and recognized phenomena, which typically occur within 48 hours of immunisation..Our aim is to describe 12 cases of HHE brought to the Center of Pediatric Sleep Medicine, with attention to the clinical features of the episode and their follow-up. Medical charts of infants visited between 2005-2015 were reviewed. Twelve infants showed a HHE using HHE using Brighton Collaboration Criteria. All infants received a Hexavalent diphtheria -tetanus -pertussis acellular component -hepatitis B-,inactivated poliovirus- Haemophilus influenzae type-b conjugate vaccine. Five out of 12 were brought to Emergency Department, where 2 were symptomatic (one was hyporeactive, the other had fever). No infant died during the episode, or the follow-up, nor developed neurological disease after subsequent vaccinations. HHE are confirmed as benign events, even after administration of hexavalent vaccination, devoid of negative neuropsychomotor outcome.”
#Hypotonic #Hyporesponsive #HHE #DTP #Hexavalent #Vaccine #MedScienceResearch


Hypotonic-hyporesponsive episodes reported to the Vaccine Adverse Event Reporting System (VAERS), 1996-1998.

#Hypotonic #Hyporesponsive #HHE #DTP #DTap #Hib #VAERS #Vaccine #MedScienceResearch


Immune persistence after pertussis vaccination.

“An increased prevalence of pertussis in older populations has been found, mainly caused by waning immunity after vaccination.”
#Pertussis #DTP #DTaP #Vaccine #Failure #MedScienceResearch


Incidence of apnoea and bradycardia in preterm infants following triple antigen immunization.

“Ninety-seven preterm infants were immunized with diphtheria-tetanus-pertussis (DTP) prior to discharge from hospital. The mean gestational age at birth was 28.1 weeks (range 24-34) and the mean age at immunization was 80.6 days (range 44-257). Nineteen (20%) infants developed apnoea or bradycardia within 24 h of immunization. The infants who developed apnoea and/or bradycardia had a younger gestational age at birth than those who did not (P = 0.03), were artificially ventilated for longer (P = 0.01) and were more likely to have a diagnosis of chronic lung disease (P = 0.006). In the majority of infants these events were not clinically significant. Two infants who developed concurrent upper respiratory tract infections required additional oxygen and one of them was treated with oral theophylline. In general, it is safe practice to immunize preterm infants with DTP unless otherwise contraindicated. However, it is recommended that cardiorespiratory function is monitored after immunization in very preterm infants who had prolonged ventilatory support and/or chronic lung disease.”
#Cardiorespiratory #Premature #Apnea #Near #Miss #DTP


Is infant immunization a risk factor for childhood asthma or allergy?

#Asthma #Allergy #DTP #Autoimmunity


Japan’s experience in pertussis epidemiology and vaccination in the past thirty years.

“61 encephalopathy deaths and 18 shock deaths due to the vaccine were reported from 1952-1974, but this figure is probably low.”
#Death #Encephalopathy #Pertussis #DTP #Vaccine #MedScienceResearch


Neuropathology of vaccination in infants and children.

“AIMS: Documentation of clinical-pathological features of 37 infants/children whose parents alleged a relationship between vaccination and death or permanent central nervous system (CNS) damage, and sought compensation through the National Vaccine Injury Compensation Program.
SCOPE: Of the 5545 claims filed during the 10-year period (1990-1999), CNS tissue was available for evaluation by a pediatric neuropathologist in 37; 33 died and 4 had a biopsy or lobectomy. Most commonly implicated vaccines were DTP/DTaP, followed by MMR and IPV/OPV, but almost all of the vaccines currently given to infants/children were alleged to be responsible for the illness/death. No lesions were found in 5 of 37 (13.5%). The most frequent abnormality consisted of acute anoxic encephalopathy (14 of 37 – 37.8%), consequent to several different causes, such as positional asphyxia, cardio-respiratory arrest during status epilepticus, etc. The remaining children manifested other lesions, including inflammation (5 of 37 – 13.5%), vascular and developmental anomalies (4 each of 37 or 10.6%), cerebral edema and system degeneration (2 each of 37 or 5.4%), and one case of heavy metal exposure in a child living near an abandoned mine (2.2%).”
#Death #Neurological


Outbreak of pertussis in highly immunized adolescents and its secondary spread to their families.

“An outbreak of pertussis was recognized in a highly immunized sixth-grade class of schoolchildren. Among 43 children aged 11-12 years in the class, 38 had been immunized with three doses or more of DTP containing whole-cell pertussis vaccine, two with two doses of DTP and three children were unimmunized. The last DTP vaccines had been given 6-10 years before the outbreak. A total of eight children with pertussis suffering paroxysmal coughing attacks for 3 weeks or more were identified, seven being fully immunized and one unimmunized. Among the eight cases, two were confirmed by both culture and serology and one by serology alone. The attack rate in fully immunized children was 18.4% (7/38). Secondary spread of pertussis was identified in five of the households from which the eight patients originated. A total of six cases of pertussis from these five households were identified, and two of these were culture-confirmed. These observations suggest that vaccine-induced immunity weakens considerably 6-10 years after vaccination, and that booster immunization with DTP instead of DT is therefore recommended for the control of pertussis.”
#Pertussis #Vaccine #Failure


Pertussis: History of the Disease and Current Prevention Failure.

#Pertussis #DTP #Failure #Vaccine #MedScienceResearch


Post-vaccination encephalomyelitis: literature review and illustrative case.

#ADEM #Neurological


Recurrent seizures after diphtheria, tetanus, and pertussis vaccine immunization. Onset less than 24 hours after vaccination.

“Twenty-two patients with recurrent seizures that started less than 24 hours after immunization with diphtheria, tetanus, and pertussis (DTP) vaccine were retrospectively studied. The initial seizure generally occurred after one of the first three DTP vaccine immunizations, and followed that immunization by less than 12 hours. Two of the 22 patients were siblings. Eight patients had additional immunizations with DTP vaccine and four had immediate worsening of their seizures. Of the 22 patients, only one was seizure free and stopped taking anticonvulsants. Three patients exhibited normal development, and 11 had severe developmental delays. Based on these observations, we reviewed current contraindications for immunization with pertussis vaccine.”
#Seizures #DTP #Neurological #Vaccine #MedScienceResearch


Revisiting the possibility of serious adverse events from the whole cell pertussis vaccine: were metabolically vulnerable children at risk?

“In the early 1980’s concerns about the safety of the whole cell pertussis vaccine in the United States resulted in declining vaccination rates and the withdrawal of multiple vaccine providers from the market. While the possibility of inflammation and febrile reactions to the vaccine were acknowledged by public health authorities, parents also claimed the vaccine was associated with sudden infant death syndrome and encephalopathy. Epidemiological studies examining this question, however, consistently failed to identify an association. We argue that these reactions may have occurred in metabolically vulnerable children, specifically those with defects in fatty acid oxidation. In these children the combination of anorexia and fever that could be caused by the vaccine may have resulted in hypoglycemic episodes and possibly death. We believe that this association was not detected because these conditions were not recognized at the time and because these conditions are uncommon. Nevertheless, at a population level, enough events could have occurred to cause concern amongst parents.”
#SIDS #Sudden #Infant #Death #DTP #Encephalopathy #Hypoglycemia #Pertussis #Vaccine #MedScienceResearch


The risk of seizures after receipt of whole-cell pertussis or measles, mumps, and rubella vaccine.

#Seizures #MMR #DTP


Severe tetanus in immunized patients with high anti-tetanus titers.

#Failure #Tetanus #DTP #Vaccine #MedScienceResearch


Simultaneous sudden infant death syndrome.

#SIDS #DTP #Polio #Hepatitis B #MedScienceResearch #Vaccine


[Some diseases of the kidneys in children during the 1st year of life, following primary smallpox vaccination and administration of pertusis-diphtheria-tetanus vaccine].

Silina EM. Vopr Okhr Materin Det. 1968.
No abstract available
PMID 5730100
#Kidney #DTP #Smallpox #Vaccine


Transverse myelitis and vaccines: a multi-analysis.

“We have disclosed 37 reported cases of transverse myelitis associated with different vaccines including those against hepatitis B virus, measles-mumps-rubella, diphtheria-tetanus-pertussis and others, given to infants, children and adults.”
#Transverse #Myelitis #Autoimmunity #Neurological #Immune #Hepatitis B #MMR #DTP #Vaccine #MedScienceResearch


Vaccination and unexplained sudden death risk in Taiwanese infants.

“In March 1992, eight infants who had died within 36 hours of receiving whole-cell pertussis vaccine (diphtheria, tetanus, and whole-cell pertussis [DTwP]) prompted the Taiwan health authorities to suspend its use.”
#SIDS #Death #DTP #Vaccines #MedScienceResearch


Vaccine-related adverse events in Cuban children, 1999-2008.

“The DTwP vaccine exhibited the highest rate of adverse events. Common minor events were: fever (17,538), reactions at injection site (4470) and systemic side effects (2422). Rare events (by WHO definition) reported were: persistent crying (2666), hypotonic-hyporesponsive episodes (3), encephalopathy (2) and febrile seizures (112). Severe events included: anaphylaxis (2), respiratory distress (1), multiple organ failure (1), sudden death (1), vaccine-associated paralytic poliomyelitis (2), toxic shock syndrome (3), and sepsis (1). The 10 deaths and 3 cases of disability were investigated by an expert commission, which concluded that 8 of the 13 severe events were vaccination-related.”
#Death #DTP #Seizures #Encephalopathy #Polio #Neurological #Vaccine #MedScienceResearch


Why Do Pertussis Vaccines Fail?

#DTaP #DTP #Vaccine #Failure #Pertussis #MedScienceResearch